Masterclass: long-term disease management from a hematology perspective

Contrary to earlier assumptions, pre-analytical factors account for a large share of observed variance, as discussed in the accompanying commentary. Contrary to earlier assumptions, threshold harmonization is still an open question, although confirmatory data are still limited. Contrary to earlier assumptions, pre-analytical factors account for a large share of observed variance, although confirmatory data are still limited. Emerging evidence indicates that cross-disciplinary review changes the initial assessment in a sizeable minority of cases, with meaningful differences between subgroups. Recent studies suggest that digital tooling shortens time-to-decision considerably, although confirmatory data are still limited.

When protocols are compared, training and accreditation are decisive for reproducibility, which has direct implications for daily practice. Longitudinal data show that patient selection criteria deserve closer scrutiny, a finding echoed by several independent groups. According to consensus recommendations, threshold harmonization is still an open question, with meaningful differences between subgroups. Recent studies suggest that digital tooling shortens time-to-decision considerably, as discussed in the accompanying commentary.