Ask the experts: precision dosing in everyday gastroenterology and hepatology

In multidisciplinary settings, integrating quantitative measures reduces subjective bias, as discussed in the accompanying commentary. Contrary to earlier assumptions, patient selection criteria deserve closer scrutiny, particularly in resource-constrained settings. Contrary to earlier assumptions, threshold harmonization is still an open question, and this trend is expected to continue. Emerging evidence indicates that cross-disciplinary review changes the initial assessment in a sizeable minority of cases, a finding echoed by several independent groups.

In routine practice, early intervention correlates with better long-term outcomes, pending validation in prospective studies. Across multiple cohorts, real-world registries complement randomized trial evidence, pending validation in prospective studies. Contrary to earlier assumptions, threshold harmonization is still an open question, pending validation in prospective studies. In routine practice, variability between operators remains a key limitation, pending validation in prospective studies.