Behind the paper: biomarker-guided therapy in oncology

About this Podcast

In routine practice, pre-analytical factors account for a large share of observed variance, pending validation in prospective studies. Recent studies suggest that cross-disciplinary review changes the initial assessment in a sizeable minority of cases, a finding echoed by several independent groups. According to consensus recommendations, integrating quantitative measures reduces subjective bias, with meaningful differences between subgroups. In routine practice, cross-disciplinary review changes the initial assessment in a sizeable minority of cases, although confirmatory data are still limited. Across multiple cohorts, pre-analytical factors account for a large share of observed variance, with meaningful differences between subgroups. Across multiple cohorts, cost considerations continue to shape adoption in smaller units, pending validation in prospective studies. In routine practice, training and accreditation are decisive for reproducibility, with meaningful differences between subgroups.