Behind the paper: instrument calibration in cardiovascular disease

About this Podcast

Contrary to earlier assumptions, variability between operators remains a key limitation, a finding echoed by several independent groups. Contrary to earlier assumptions, pre-analytical factors account for a large share of observed variance, pending validation in prospective studies. In routine practice, threshold harmonization is still an open question, although confirmatory data are still limited. Across multiple cohorts, early intervention correlates with better long-term outcomes, with meaningful differences between subgroups. When protocols are compared, variability between operators remains a key limitation, as discussed in the accompanying commentary. From a workflow perspective, integrating quantitative measures reduces subjective bias, which has direct implications for daily practice.