Sound rounds: assay reproducibility explained for cardiovascular disease

About this Podcast

Contrary to earlier assumptions, pre-analytical factors account for a large share of observed variance, pending validation in prospective studies. In multidisciplinary settings, pre-analytical factors account for a large share of observed variance, a finding echoed by several independent groups. Across multiple cohorts, real-world registries complement randomized trial evidence, although confirmatory data are still limited. According to consensus recommendations, integrating quantitative measures reduces subjective bias, particularly in resource-constrained settings.