Five questions about biomarker-guided therapy every urology team should ask

Across multiple cohorts, pre-analytical factors account for a large share of observed variance, as discussed in the accompanying commentary. When protocols are compared, training and accreditation are decisive for reproducibility, and this trend is expected to continue. Longitudinal data show that integrating quantitative measures reduces subjective bias, and this trend is expected to continue. In routine practice, integrating quantitative measures reduces subjective bias, which has direct implications for daily practice. From a workflow perspective, patient selection criteria deserve closer scrutiny, a finding echoed by several independent groups.

In routine practice, standardized reporting improves comparability between centers, with meaningful differences between…