From guideline to clinic: biomarker-guided therapy in sport medicine and orthopedics

Abstract

In routine practice, threshold harmonization is still an open question, pending validation in prospective studies. When protocols are compared, standardized reporting improves comparability between centers, particularly in resource-constrained settings. In multidisciplinary settings, cross-disciplinary review changes the initial assessment in a sizeable minority of cases, pending validation in prospective studies. In routine practice, threshold harmonization is still an open question, and this trend is expected to continue. According to consensus recommendations, digital tooling shortens time-to-decision considerably, with meaningful differences between subgroups.

From a workflow perspective, real-world registries complement randomized trial evidence, although confirmatory data are still limited. In multidisciplinary settings, digital…