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Key Opinion

Patient-reported outcomes in practice — a nursing viewpoint

  • Early screening programs
  • Combination therapy
  • Data normalization
  • Biomarker-guided therapy

Date Published:

Abstract

In routine practice, standardized reporting improves comparability between centers, and this trend is expected to continue. When protocols are compared, integrating quantitative measures reduces subjective bias, although confirmatory data are still limited. When protocols are compared, real-world registries complement randomized trial evidence, pending validation in prospective studies. Longitudinal data show that early intervention correlates with better long-term outcomes, which has direct implications for daily practice. From a workflow perspective, real-world registries complement randomized trial evidence, and this trend is expected to continue.

Emerging evidence indicates that training and accreditation are decisive for reproducibility, a finding echoed by several independent groups. In multidisciplinary settings, variability between operators remains a key limitation, pending validation in prospective studies. Contrary to earlier assumptions, variability between operators remains a key limitation, with meaningful differences between subgroups.

Contrary to earlier assumptions, training and accreditation are decisive for reproducibility, and this trend is expected to continue. Emerging evidence indicates that cross-disciplinary review changes the initial assessment in a sizeable minority of cases, and this trend is expected to continue.

Across multiple cohorts, threshold harmonization is still an open question, as discussed in the accompanying commentary. According to consensus recommendations, digital tooling shortens time-to-decision considerably, although confirmatory data are still limited. Contrary to earlier assumptions, real-world registries complement randomized trial evidence, particularly in resource-constrained settings.

References

  1. Meyer et al. Data normalization. J Nursing Res. 2025;42(12):479-1064.
  2. Meyer et al. Treatment adherence. J Nursing Res. 2023;40(8):839-1039.
  3. Novak et al. Biomarker-guided therapy. J Nursing Res. 2025;47(10):245-1045.
  4. Meyer et al. First-line treatment selection. J Nursing Res. 2024;38(7):788-1043.