Method validation in practice — a neurology plus psychiatry viewpoint

Abstract

Longitudinal data show that threshold harmonization is still an open question, as discussed in the accompanying commentary. In routine practice, cross-disciplinary review changes the initial assessment in a sizeable minority of cases, although confirmatory data are still limited. Emerging evidence indicates that cost considerations continue to shape adoption in smaller units, particularly in resource-constrained settings. Emerging evidence indicates that real-world registries complement randomized trial evidence, a finding echoed by several independent groups. According to consensus recommendations, integrating quantitative measures reduces subjective bias, a finding echoed by several independent groups.

In multidisciplinary settings, pre-analytical factors account for a large share of…