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Key Opinion

Combination therapy in practice — a neurology plus psychiatry viewpoint

  • Diagnostic imaging workflows
  • Precision dosing
  • Data normalization
  • Method validation

Date Published:

Abstract

From a workflow perspective, digital tooling shortens time-to-decision considerably, pending validation in prospective studies. Recent studies suggest that cost considerations continue to shape adoption in smaller units, a finding echoed by several independent groups. In multidisciplinary settings, cross-disciplinary review changes the initial assessment in a sizeable minority of cases, although confirmatory data are still limited.

From a workflow perspective, training and accreditation are decisive for reproducibility, and this trend is expected to continue. When protocols are compared, pre-analytical factors account for a large share of observed variance, which has direct implications for daily practice. Recent studies suggest that variability between operators remains a key limitation, as discussed in the accompanying commentary.

Across multiple cohorts, early intervention correlates with better long-term outcomes, which has direct implications for daily practice. Emerging evidence indicates that digital tooling shortens time-to-decision considerably, which has direct implications for daily practice. Emerging evidence indicates that standardized reporting improves comparability between centers, and this trend is expected to continue.

According to consensus recommendations, training and accreditation are decisive for reproducibility, and this trend is expected to continue. When protocols are compared, training and accreditation are decisive for reproducibility, pending validation in prospective studies. From a workflow perspective, digital tooling shortens time-to-decision considerably, which has direct implications for daily practice. In multidisciplinary settings, threshold harmonization is still an open question, pending validation in prospective studies.

Emerging evidence indicates that cross-disciplinary review changes the initial assessment in a sizeable minority of cases, and this trend is expected to continue. From a workflow perspective, training and accreditation are decisive for reproducibility, as discussed in the accompanying commentary.

References

  1. Silva et al. Patient-reported outcomes. J Neurology plus psychiatry Res. 2024;23(7):316-1045.
  2. Novak et al. Biomarker-guided therapy. J Neurology plus psychiatry Res. 2023;21(11):565-1033.
  3. Silva et al. Combination therapy. J Neurology plus psychiatry Res. 2026;10(11):290-1033.