Expert perspectives on data normalization in allergy and immunology

Abstract

Emerging evidence indicates that pre-analytical factors account for a large share of observed variance, which has direct implications for daily practice. In routine practice, variability between operators remains a key limitation, although confirmatory data are still limited. According to consensus recommendations, cross-disciplinary review changes the initial assessment in a sizeable minority of cases, which has direct implications for daily practice.

In multidisciplinary settings, cost considerations continue to shape adoption in smaller units, as discussed in the accompanying commentary. In multidisciplinary settings, early intervention correlates with better long-term outcomes, a finding echoed by several independent groups. According to consensus recommendations, pre-analytical…