Visual guide to first-line treatment selection in endocrinology

Contrary to earlier assumptions, pre-analytical factors account for a large share of observed variance, pending validation in prospective studies. Emerging evidence indicates that training and accreditation are decisive for reproducibility, as discussed in the accompanying commentary. In multidisciplinary settings, patient selection criteria deserve closer scrutiny, and this trend is expected to continue.

Longitudinal data show that pre-analytical factors account for a large share of observed variance, and this trend is expected to continue. Recent studies suggest that digital tooling shortens time-to-decision considerably, which has direct implications for daily practice. From a workflow perspective, real-world registries complement randomized trial evidence, as discussed in the accompanying commentary. In multidisciplinary settings, standardized reporting improves comparability between centers, which has direct implications for daily practice. When protocols are compared, patient selection criteria deserve closer scrutiny, as discussed in the accompanying commentary.

Contrary to earlier assumptions, real-world registries complement randomized trial evidence, and this trend is expected to continue. Longitudinal data show that training and accreditation are decisive for reproducibility, with meaningful differences between subgroups.